Applications of Cobetter Lifemeta™ STF TPE Tubing

Cobetter Lifemeta™ STF TPE tubing is extruded from medical-grade thermoplastic elastomer (TPE) material, with excellent heat sealing and sterile welding performance. The Lifemeta™ STF has demonstrated considerable welding compatibility and weldability in comparison to the leading TPE tubes in the market. Its design and manufacturing meet the highest requirements of the Good Manufacturing Practice (GMP) for safety, efficacy, and quality control.

Features and Benefits of Cobetter Lifemeta™ STF TPE Tubing

• Excellent low Leachables & Extractables: Made of high purity medical-grade raw materials
• Animal-Derived Component Free (ADCF): Products do not contain animal derived components and are free from TSE risk.
• Extremely Low Cytotoxicity: Meet the requirement of USP <87> In Vitro Biological Reactivity Test.
• Low Gas Permeability: Prevents the unintended ingress or egress of gases like oxygen and carbon dioxide, which is critical for gas-sensitive cell cultures.
• Broad Chemical Compatibility: Resists a wide range of chemicals, superior DMSO compatibility.
• Quality Assurance: Meet the requirements of ISO 9001:2015 and cGMP. 

Lifemeta™ STF TPE Tubing is Suitable for Use with Peristaltic Pumps

Upstream Application from A CDMO Company

The liquid transfer across Class C areas requires passing a wall-through system. The whole process is accomplished via a peristaltic pump and takes about one hour. Aseptic connectors and disconnectors are necessary before and after the transfer.

Based on technical evaluation and testing by Cobetter's team, the Lifemeta™ STF TPE tubing solution is recommended. A single thermoplastic elastomer tubing can meet the above operational requirements while reducing risks and costs.

Lifemeta™ STF TPE tubing — Lower Gas Permeability

Inject gas into the tubing and keep its internal pressure as stable as at 2000mbar, record gas transmission rate diffused from different tubing after 10 minutes of pressure stabilization.

Testing results indicate that Lifemeta™ STF TPE tubing exhibits lower gas permeability, making it a suitable choice for upstream bioreactor applications. 

Lifemeta™ STF TPE tubing — Extremely Low Cytotoxicity

Lifemeta™ STF TPE tubing is extruded from medical-grade thermoplastic elastomer materials. It is specially designed for applications such as perfusion culture and Wave bioreactor bags, where cytotoxicity is a critical factor in raw material assessment.

Testing results indicate that Lifemeta™ STF TPE tubing exhibits lower cytotoxicity in upstream cell culture applications. 

Lifemeta™ STF TPE tubing — Reliable Welding and Sealing, Compatible with TPE Tubing from Other Brands

Cobetter validation team evaluates the welding and sealing performance of thermoplastic elastomer tubing with following aspects: seal integrity testing (water intrusion pressure hold method, bacterial challenge), tensile strength of the weld joint, burst strength, internal and external surface condition of the weld area, and welding residue analysis.

Beyond routine testing, Lifemeta™ STF TPE tubing has undergone extensive validation and practical application with various pharmaceutical product categories, with its welding strength and stability earning customer recognition. 

For specialized process conditions such as freeze-thaw applications and ADC (Antibody-Drug Conjugate) products, Lifemeta™ STF TPE tubing can also serve as a novel solution.

A customer from freeze-thaw applications said: The weld integrity of Lifemeta™ STF TPE tubing remains robust even after exposure to -80°C freeze-thaw cycles.

In the application of ADC products, Lifemeta™ STF TPE tubing exhibits superior DMSO compatibility compared to silicone tubing.

Conclusion

Cobetter's comprehensive aseptic connection and disconnection solutions, including Lifemeta™ STF TPE tubing, tube sealers, aseptic connectors and disconnectors, together with aseptic metallic sleeve, can meet the requirements for sterile fluid transfer across multiple process stages, from upstream cell culture to downstream formulation production.

Order information of Lifemeta™ STF TPE tubing

Standard package of tubing length: 15m/50feet
Delivery condition: Non sterile
Sterilizing methods: 1. By gamma irradiated at 25-45 kGy and can not be re-sterilized; 2. Can be autoclaved 25 cycles for 30 minutes at 121 °C