Home Products Industrial Liquid Filter Cartridges DLHPVHBR/LHPVHBR Sterilizing-Grade Liquid Filter

DLHPVHBR/LHPVHBR Sterilizing-Grade Liquid Filter

Cobetter's DLHPVHBR/LHPVHBR series filter cartridge is made of hydrophilic and positively-charged PVDF membrane. PVDF's unique very low protein adsorption performance makes it particularly suitable for filtration of culture fluids, biological reagents, sterile vaccines, etc. At the same time, DLHPVHBR/LHPVHBR has low leachables, wide chemical compatibility, and very excellent temperature resistance.

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Description Specifications Ordering Information

Description

Features

Very low protein adsorption properties
Good corrosion, oxidation and heat resistance
Low leachables
Good chemical compatibility
100% integrity testing to ensure sterilization performance

Applications

Blood product filtration
Antibiotic solution sterile filtration
Biological reagent filtration
Vaccine filtration

Quality

100% Integrity testing in manufacturing
Each filter is fully traceable with unique serial number
Manufactured in a facility which adheres to ISO 9001:2015 Practices

Flow Rate Characteristics

Specifications

Materials of Construction

Membrane	Hydrophilic polyvinylidene fluoride (PVDF)
Support	Polypropylene (PP)
Core/Cage/End Caps	Polypropylene (PP)
End Cap Inserts	Polybutylene terephthalate (PBT)
Seal Material	Silicone / EPDM / Viton FEP/ PFA encapsulated O-rings

Operating Conditions

Max. Operating Temperature	80°C
Max.Operating Pressure	0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C
Max. Differential Pressure (Forward)	0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C
Max. Differential Pressure (Reverse)	0.30 MPa@25°C 0.10 MPa@80°C

Filtration Area

	Outer Diameter	Membrane Pore Size	Area/10"
DLHPVHBR	69 mm	0.1+0.1 μm	0.58 m²
	69 mm	0.22+0.1 μm	0.58 m²
	69 mm	0.22+0.22 μm	0.58 m²
	69 mm	0.45+0.22 μm	0.58 m²
	69 mm	0.65+0.22 μm	0.58 m²
LHPVHBR	69 mm	0.22 μm	0.58 m²
LHPVHBR	69 mm	0.45 μm	0.58 m²

Integrity Test Standards @10inch，20°C (DLHPVHBR)

Membrane Pore Size	Bubble Point	Air Diffusion
0.1+0.1 μm	≥ 0.48 MPa (water), Air Testing	≤ 15 ml/min @ 0.386 MPa (water)
0.22+0.1 μm	≥ 0.48 MPa (water), Air Testing	≤ 20 ml/min @ 0.386 MPa (water)
0.22+0.22 μm	≥ 0.32 MPa (water), Air Testing	≤ 18 ml/min @ 0.28 MPa (water)
0.45+0.22 μm	≥ 0.32 MPa (water), Air Testing	≤ 20 ml/min @ 0.28 MPa (water)
0.65+0.22 μm	≥ 0.32 MPa (water), Air Testing	≤ 20 ml/min @ 0.28 MPa (water)

Integrity Test Standards @10inch，20°C (LHPVHBR)

Membrane Pore Size	Bubble Point	Air Diffusion
0.1 μm	/	≤ 30 ml/min @ 0.386 MPa (water)
0.22 μm	≥ 0.32 MPa (water), Air Testing	≤ 20 ml/min @ 0.28 MPa (water)
0.45 μm	≥ 0.12 MPa (water), Air Testing	≤ 10 ml/min @ 0.10 MPa (water)

Bacterial Retention

Model	Content
DLHPVHBR 0.22+0.1μm	Bacterial quantitative retention of 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology.
DLHPVHBR 0.22+0.22μm
DLHPVHBR 0.22+0.1μm
DLHPVHBR 0.45+0.22μm
DLHPVHBR 0.65+0.22μm
LHPVHBR 0.1μm	Bacterial quantitative retention of 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology.
LHPVHBR 0.22μm

Sterilization

In-line steam sterilization	DLHPVHBR Up to 150 cycles (135°C for 30 min, differential pressure <30kPa in the forward direction with 100 cycles and <10kPa in the reverse direction with 50 cycles) LHPVHBR Up to 70 cycles (135°C for 30 min and differential pressure <30kPa)
Autoclave	Up to 400 cycles (130 °C for 30 min per cycle)

Regulatory Compliance

Autoclaved filter effluent meets the USP<788> requirement of particulate matter in large volume injection.
Component materials meet the criteria for a "Non-fiber-releasing filter" as defined in 21 CFR 210.3(b)(6).
Aqueous extraction from a cartridge contains less than 0.25EU/ml as determined by Limulus Amebocyte Lysate (LAL), meeting requirements of USP<85>.
Meet the requirement of USP <87> In Vitro Cytotoxicity Test.
Component materials meet the requirements of the current USP<88> for plastic class VI-121°C.
All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177-182.
Based on the current information from our suppliers, all component materials used in the manufacture of this product are animal-free.

End Cap

Ordering Information

DLHPVHBR (Double-layer)

Outer Diameter	Type	Membrane Pore Size	End Cap	Nominal Length	Seal Material	Industry
69mm	DLHPVHBR	1010 0.1+0.1µm	DOE Double Open End	05 5 inch	S Silicone	P
		2210 0.22+0.1µm	HTF 222/Fin	10 10 inch	E EPDM
		2222 0.22+0.22µm	HSF 226/Fin	20 20 inch	V Viton
		4522 0.45+0.22µm	HTCG 222/Flat	30 30 inch	P FEP/PFA encapsulated O-rings
		6522 0.65+0.22µm	HSCG 226/Flat	40 40 inch

LHPVHBR (Single-layer)

Outer Diameter	Type	Membrane Pore Size	End Cap	Nominal Length	Seal Material	Industry
69mm	LHPVHBR	0022 0.22µm	DOE Double Open End	05 5 inch	S Silicone	P
		0045 0.45μm	HTF 222/Fin	10 10 inch	E EPDM
			HSF 226/Fin	20 20 inch	V Viton
			HTCG 222/Flat	30 30 inch	P FEP/PFA encapsulated O-rings
			HSCG 226/Flat	40 40 inch

* Example：DLHPVHBR1010DOE05SP (DLHPVHBR，0.1+0.1µm，Double open end，5 inch，Silicone，Pharmaceutical)