Home Products Industrial Liquid Filter Cartridges DLHPVDF/LHPVDF Sterilizing-Grade Liquid Filter

DLHPVDF/LHPVDF Sterilizing-Grade Liquid Filter

Cobetter DLHPVDF series cartridges are made of double-layer hydrophilic PVDF membranes; PVDF has very low protein adsorption properties, making it especially suitable for culture fluid, biological reagents, sterile vaccine filtration. At the same time, DLHPVDF has low leachables, wide chemical compatibility, and very excellent temperature resistance.

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Description Specifications Ordering Information

Description

Features

Very low protein adsorption properties
Good corrosion, oxidation and heat resistance
Low leachables
Good chemical compatibility
100% integrity testing to ensure sterilization performance

Applications

Blood products filtration
Culture media filtration
Antibiotic sterile filtration
Biological reagents filtration
Vaccine filtration

Quality

100% Integrity testing in manufacturing
Each filter is fully traceable with unique serial number
Manufactured in a facility which adheres to ISO 9001:2015 Practices

Flow Rate Characteristics

Specifications

Materials of Construction

Membrane	Hydrophilic polyvinylidene fluoride (PVDF)
Support	Polypropylene (PP)
Core/Cage/End Caps	Polypropylene (PP)
End Cap Inserts	Polybutylene terephthalate (PBT)
Seal Material	Silicone / EPDM / Viton FEP/ PFA encapsulated O-rings

Operating Conditions

Max. Operating Temperature	80°C
Max.Operating Pressure	0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C
Max. Differential Pressure (Forward)	0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C
Max. Differential Pressure (Reverse)	0.30 MPa@25°C 0.10 MPa@80°C

Filtration Area

	Outer Diameter	Membrane Pore Size	Area/10"
DLHPVDF	69 mm	0.22+0.1 μm	0.55 m²
	69 mm	0.22+0.22 μm	0.55 m²
	69 mm	0.45+0.22 μm	0.55 m²
	69 mm	0.45+0.45 μm	0.58 m²
	69 mm	0.65+0.45 μm	0.58 m²
LHPVDF	69 mm	0.1 μm	0.58 m²
	69 mm	0.22 μm	0.58 m²
	69 mm	0.45 μm	0.58 m²
	69 mm	0.65 μm	0.58 m²

Integrity Test Standards @10inch，20°C (DLHPVDF)

Membrane Pore Size	Bubble Point	Air Diffusion
0.22+0.22 μm	≥ 0.32 MPa (water), Air Testing	≤ 16 ml/min @ 0.28 MPa (water)
0.45+0.22 μm	≥ 0.32 MPa (water), Air Testing	≤ 20 ml/min @ 0.28 MPa (water)
0.45+0.45 μm	≥ 0.16 MPa (water), Air Testing
0.65+0.45 μm	≥ 0.12 MPa (water), Air Testing	≤ 10 ml/min @ 0.1 MPa (water)

Integrity Test Standards @10inch，20°C (LHPVDF)

Membrane Pore Size	Bubble Point	Air Diffusion
0.1 μm	≥ 0.16 MPa，Wetted with 60% IPA, Air Test	≤ 30 ml/min @ 0.386 MPa，Water Wetting
0.22 μm	≥ 0.32 MPa，Water wetting, Air Testing	≤ 20 ml/min @ 0.28 MPa，Water Wetting
0.45 μm	≥ 0.12 MPa，Water wetting, Air Testing	≤ 10 ml/min @ 0.10 MPa，Water Wetting
0.65 μm	≥ 0.10 MPa，Water Wetting, Air Testing

Bacterial Retention

Model	Content
DLHPVDF 0.22+0.22 μm	Bacterial quantitative retention of 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology.
DLHPVDF 0.45+0.22μm
DLHPVDF 0.45+0.45 μm	Bacterial quantitative retention of 10⁷ cfu/cm² Serratia marcescens (ATCC14756) according to ASTM F838 methodology.
DLHPVDF 0.65+0.45 μm
LHPVDF 0.1μm	Bacterial quantitative retention of 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology.
LHPVDF 0.22μm
LHPVDF 0.45 μm	Bacterial quantitative retention of 10⁷ cfu/cm² Serratia marcescens (ATCC14756) according to ASTM F838 methodology.

Sterilization

In-line steam sterilization	Up to 50 cycles (135°C for 30 min and differential pressure < 30 kPa per cycle)
Autoclave	Up to 50 cycles (130°C for 30 min per cycle)

Regulatory Compliance

Autoclaved filter effluent meets the USP<788> requirement of particulate matter in large volume injection.
Component materials meet the criteria for a "Non-fiber-releasing filter" as defined in 21 CFR 210.3(b)(6).
Aqueous extraction from a cartridge contains less than 0.25EU/ml as determined by Limulus Amebocyte Lysate (LAL), meeting requirements of USP<85>.
Meet the requirement of USP <87> In Vitro Cytotoxicity Test.
Component materials meet the requirements of the current USP<88> for plastic class VI-121°C.
All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177-182.
Based on the current information from our suppliers, all component materials used in the manufacture of this product are animal-free.

End Cap

Ordering Information

DLHPVDF (Double-layer)

Outer Diameter	Type	Membrane Pore Size	End Cap	Nominal Length	Seal Material	Industry
69mm	DLHPVDF	2210 0.22+0.1µm	DOE Double Open End	05 5 inch	S Silicone	P
		2222 0.22+0.22µm	HTF 222/Fin (PBT insert)	10 10 inch	E EPDM
		4522 0.45+0.22µm	HSF 226/Fin (PBT insert)	20 20 inch	V Viton
		4545 0.45+0.45µm	HTCG 222/Flat (PBT insert)	30 30 inch	P FEP/PFA encapsulated O-rings
		6545 0.65+0.45µm	HSCG 226/Flat (PBT insert)	40 40 inch

LHPVDF (Single-layer)

Outer Diameter	Type	Membrane Pore Size	End Cap	Nominal Length	Seal Material	Industry
69mm	LHPVDF	0010 0.1µm	DOE Double Open End	05 5 inch	S Silicone	P
		0022 0.22μm	HTF 222/Fin (PBT insert)	10 10 inch	E EPDM
		0045 0.45μm	HSF 226/Fin (PBT insert)	20 20 inch	V Viton
		0065 0.65μm	HTCG 222/Flat (PBT insert)	30 30 inch	P FEP/PFA encapsulated O-rings
			HSCG 226/Flat (PBT insert)	40 40 inch

* Example：DLHPVDF2210DOE05SP (DLHPVDF，0.22+0.1µm，Double open end，5 inch，Silicone，Pharmaceutical)