Monoclonal Antibody

The manufacturing of monoclonal antibody includes cell line development, purification, formulation and final fill. Membrane filtration is an indispensable step in the production of antibody drugs. Cobetter have more than 10 years of experience in developing and optimizing mAb processes with customers. For the production of antibodies, combinations of efficient and fast membrane filtration products, TFF systems and safe & reliable disposable solutions are available from Cobetter.

mAbs Production Workflow

Upstream-Media Preparation

Cobetter Lifecube® mixing bags for mixing of CHO media contain an in-center magnetic impeller assembly and are available in a range from 50 L to 2000 L.

Mixers

Mixing Bags for media preparation

Aseptic Connections

Mycoplasma Removal

Purcise® MLE -Double Layer PES

Vent & Gas Filtration

Cobetter hydrophobic PTFE and PVDF filters are widely used as air and gas sterilizing filters and idear for sterile venting of your single-use systems. They are available in different formats of syringe filters, capsule filters and cartridge filters.

Safesure® AFM -Hydrophobic PTFE

Corevital® APB -Hydrophobic PVDF

Aegivast® ACE -Hydrophobic PTFE

Cell Harvest

Cobetter Depth Filters are cellulose-based filters developed for demanding clarification applications. The wide range of grades offers a solution for clarification or direct bioreactor harvest.

Roheap® CSD Depth Filters

Membrane Chromatography

Membrane Chromatography eliminates packing and cleaning validation, and has flow rates up to 20 times faster than traditional column chromatography.

Virus Filtration

Cobetter Lifecube® mixing bags for mixing of CHO media contain an in-center magnetic impeller assembly and are available in a range from 50 L to 2000 L.