Blogs
E. coli Expression(CRM197) Ammonium Sulfate Precipitation Collection, Redissolution, Clarification
Ammonium sulfate precipitation can be used to concentrate and partially purify proteins from large amounts of crude preparations. High concentrations of saline ions in the protein solution can compete with water...
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Lifemeta™ Tube Sealer
In the global biopharmaceutical industry, production processes relying on single-use solutions are extensively employed. Achieving aseptic and reliable disconnection of tubing connected to single-use bioprocessing products, such as mixing bags and storage...
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Introduction to Cobetter Composite Fiber Depth Filters
With the continuous advancement of upstream cell culture processes in the biotechnology industry, the expression levels of target proteins are increasing, leading to higher cell densities in production. Consequently, the...
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How to Select the Correct MWCO for DNA, RNA and Protein Purification and Concentration
What is MWCO? Molecular weight cut-off (MWCO) is a term in membrane filtration to describe the pore size or rejection capability of an ultrafiltration membrane. The MWCO of an ultrafiltration membrane is a nominal rating...
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How to Choose MWCO Filters?
MWCO filters, also known as centrifugal filters, are commonly used lab ultrafiltration devices for the concentration, purification and buffer exchange of polynucleotides and protein samples. To select the appropriate ultrafiltration MWCO...
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Low Extractable Nylon Filter Membrane Solve the Trouble of Interfering Peaks in HPLC
HPLC HPLC is a highly precise analytical instrument used for liquid sample analysis. Prior to HPLC analysis, it is crucial to filter the sample and mobile phase to remove insoluble...
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Cobetter CP Series Wall-through Components for Safe Fluid Transfer between Clean Rooms
Are you worried about the transfer of liquid materials across clean rooms during the production process? Are you worried about the risk of breakage or leakage when using traditional material...
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mRNA Vaccine Manufacturing Strategy 2 - IVT in mRNA Production
IVT in mRNA production As a potential new therapeutic drug solution, mRNA has been planned or developed for the research of many intractable diseases such as oncology, epidemiology, vaccine immunology...
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Cobetter’s Single-use Systems for Antibody Manufacturing
Antibodies, also known as immunoglobulins (Ig), are glycoproteins that can specifically bind to antigens. Common antibodies include monoclonal antibodies, bispecific antibodies, polyclonal antibodies, and ADC, FC fusion proteins. In the...
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Aseptic Sampling Methods in Pharmaceutical Manufacturing
Over the past few years, due to the significant expansion of the biopharmaceutical field, stricter validation standards, and a better comprehension of Quality by Design (QbD) and Process Analytical Technology...
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The Application of Hollow Fiber Filter in Plasmid and Virus Manufacturing
In the development of processes for plasmid concentration, viral vector and vaccine purification, the application of ultrafiltration technology is indispensable. Hollow fiber filters, with their simple structure, low shear stress,...
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Introduction to Inline Spiking Technology for Virus Removal Validation
Virus removal filters are widely used in biologics downstream processes to control the risk of viral contamination. At the end of the virus removal filtration selection optimization test, a virus spiking...
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